| Rank | Player | Team | ER |
|---|---|---|---|
| 1 |  Jesus Luzardo |  | 23 |
| 2 |  Kyle Freeland |  | 21 |
| 3 | Sixto Sanchez |  | 14 |
| 4 |  Pablo Lopez |  | 14 |
| 5 | Chris Sale |  | 13 |
| 6 |  Lucas Sims | | 12 |
| 7 | Corbin Burnes | | 12 |
| 8 | Sandy Alcantara |  | 11 |
| 9 | Lance Lynn |  | 11 |
| 10 |  Miles Mikolas | | 11 |
| 11 | Brendan McKay | | 11 |
| 12 |  Trent Thornton |  | 11 |
| 13 |  Clayton Kershaw | | 9 |
| 14 | Merrill Kelly |  | 9 |
| 15 | Tyler Chatwood | | 9 |
| 16 | Garrett Richards |  | 9 |
| 17 |  Jacob DeGrom | | 9 |
| 18 | J.B. Wendelken | | 9 |
| 19 |  Jake Odorizzi |  | 8 |
| 20 | Brandon Kintzler | | 8 |
