| Rank | Player | Team | L |
|---|---|---|---|
| 1 |  Pablo Lopez |  | 3 |
| 2 |  Kyle Freeland |  | 2 |
| 3 | Kyle Hendricks |  | 2 |
| 4 | David Price |  | 2 |
| 5 | Corbin Burnes |  | 2 |
| 6 | Chris Sale |  | 2 |
| 7 | Aaron Civale | | 2 |
| 8 |  Jesus Luzardo |  | 2 |
| 9 |  Jacob DeGrom | | 2 |
| 10 | Carlos Carrasco | | 2 |
| 11 | Sixto Sanchez | | 1 |
| 12 | Yu Darvish |  | 1 |
| 13 |  Jake Odorizzi |  | 1 |
| 14 | Sean Newcomb |  | 1 |
| 15 | Liam Hendricks |  | 1 |
| 16 |  Jose Berrios | | 1 |
| 17 | Nathan Eovaldi |  | 1 |
| 18 |  Kenta Maeda | | 1 |
| 19 | Anibal Sanchez |  | 1 |
| 20 | Tyler Glasnow | | 1 |
